Neurologic manifestations in hospitalized patients with COVID‐19

Background To investigate the effect of pre-existing neurological symptoms and disease in coronavirus 2019 (COVID-19) health outcomes a large Illinois-based cohort. Method A multicenter retrospective study analyzed differences cohort COVID-19 positive patients with without baseline or admitted to RUSH University Systems for Health from March November 2020. We measured sex outcome hospitalization rates, during initial admission, complications, readmissions, mortality two groups. Result Of total 1708 hospitalized (mean age: 58.04, 930 males) — 31% [527] had history and/or disease, 9% [140] dementia. Nonspecific including myalgia (19%), headache (11%), epilepsy (0.8%), tremors (3%), abdominal pain (11%) were reported more frequently neurologic history. Female conditions than their male counterparts (40% versus 24%). Compared those no conditions, higher rates such as acute myocardial infarction (13% vs. 8%; p = 0.002) deep vein thrombosis/pulmonary embolism (14% 10%; 0.02). Multivariate analysis showed that stroke migraines are independently associated readmission hospital floor (generalized linear model, z 2.092, 3.320, 0.036, < 0.001, respectively); readmitted, 13% died hospital, 6% Conclusion Neurologic manifestations common complications hospitalization. The increasing evidence SARS CoV-2’s impact on central nervous system raises important questions long-term consequences this virus brain injury.